| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 16/09/25 18:45 | Athletic Club | Arsenal FC | -:- |
| 16/09/25 18:45 | PSV Eindhoven | Royale Union Saint-Gilloise | -:- |
| 16/09/25 21:00 | Tottenham | Villarreal C. F. | -:- |
| 16/09/25 21:00 | Benfica Lisboa | Qarabag | -:- |
| 16/09/25 21:00 | Juventus de Turin | Borussia Dortmund | -:- |
| 16/09/25 21:00 | Real Madrid C. F. | Olympique Marseille | -:- |
| 17/09/25 18:45 | Olympiacos Piräus | Pafos FC | -:- |
| 17/09/25 18:45 | Slavia Praga | FK Bodö/Glimt | -:- |
| 17/09/25 21:00 | Paris St. Germain | Atalanta Bergamo | -:- |
| 17/09/25 21:00 | Liverpool FC | Club Atlético de Madrid | -:- |
| 17/09/25 21:00 | Ajax Amsterdam | Inter de Milán | -:- |
| 17/09/25 21:00 | FC Bayern de Múnich | FC Chelsea | -:- |
| 18/09/25 18:45 | Club Brujas | AS Monaco | -:- |
| 18/09/25 18:45 | FC Copenhague | Bayer Leverkusen | -:- |
| 18/09/25 21:00 | Sporting de Portugal | Qairat Almaty | -:- |
| 18/09/25 21:00 | Eintracht Frankfurt | Galatasaray Estanbul | -:- |
| 18/09/25 21:00 | Manchester City | Nápoles | -:- |
| 18/09/25 21:00 | Newcastle United | F. C. Barcelona | -:- |