| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 21/10/25 18:45 | F. C. Barcelona | Olympiacos Piräus | 6:1 |
| 21/10/25 18:45 | Kairat Almaty | Pafos FC | 0:0 |
| 21/10/25 21:00 | PSV Eindhoven | Nápoles | 6:2 |
| 21/10/25 21:00 | Villarreal C. F. | Manchester City | 0:2 |
| 21/10/25 21:00 | FC Copenhague | Borussia Dortmund | 2:4 |
| 21/10/25 21:00 | Royale Union Saint-Gilloise | Inter de Milán | 0:4 |
| 21/10/25 21:00 | Arsenal FC | Club Atlético de Madrid | 4:0 |
| 21/10/25 21:00 | Newcastle United | Benfica Lisboa | 3:0 |
| 21/10/25 21:00 | Bayer Leverkusen | Paris St. Germain | 2:7 |
| 22/10/25 18:45 | Galatasaray Estanbul | FK Bodö/Glimt | 3:1 |
| 22/10/25 18:45 | Athletic Club | Qarabag | 3:1 |
| 22/10/25 21:00 | Real Madrid C. F. | Juventus de Turin | 1:0 |
| 22/10/25 21:00 | FC Bayern de Múnich | Club Brujas | 4:0 |
| 22/10/25 21:00 | FC Chelsea | Ajax Amsterdam | 5:1 |
| 22/10/25 21:00 | Eintracht Frankfurt | Liverpool FC | 1:5 |
| 22/10/25 21:00 | Atalanta Bergamo | Slavia Praga | 0:0 |
| 22/10/25 21:00 | Sporting de Portugal | Olympique Marseille | 2:1 |
| 22/10/25 21:00 | AS Monaco | Tottenham | 0:0 |