| Fecha | Local | Visitante | Resultado |
|---|---|---|---|
| 9/12/25 16:30 | Kairat Almaty | Olympiacos Piräus | 0:1 |
| 9/12/25 18:45 | FC Bayern de Múnich | Sporting de Portugal | 3:1 |
| 9/12/25 21:00 | AS Monaco | Galatasaray Estanbul | 1:0 |
| 9/12/25 21:00 | F. C. Barcelona | Eintracht Frankfurt | 2:1 |
| 9/12/25 21:00 | PSV Eindhoven | Club Atlético de Madrid | 2:3 |
| 9/12/25 21:00 | Atalanta Bergamo | FC Chelsea | 2:1 |
| 9/12/25 21:00 | Tottenham | Slavia Praga | 3:0 |
| 9/12/25 21:00 | Royale Union Saint-Gilloise | Olympique Marseille | 2:3 |
| 9/12/25 21:00 | Inter de Milán | Liverpool FC | 0:1 |
| 10/12/25 18:45 | Villarreal C. F. | FC Copenhague | 2:3 |
| 10/12/25 18:45 | Qarabag | Ajax Amsterdam | 2:4 |
| 10/12/25 21:00 | Athletic Club | Paris St. Germain | 0:0 |
| 10/12/25 21:00 | Bayer Leverkusen | Newcastle United | 2:2 |
| 10/12/25 21:00 | Borussia Dortmund | FK Bodö/Glimt | 2:2 |
| 10/12/25 21:00 | Club Brujas | Arsenal FC | 0:3 |
| 10/12/25 21:00 | Juventus de Turin | Pafos FC | 2:0 |
| 10/12/25 21:00 | Real Madrid C. F. | Manchester City | 1:2 |
| 10/12/25 21:00 | Benfica Lisboa | Nápoles | 2:0 |